Sarcoidosis is a systemic disorder characterized by non-necrotizing granulomatous inflammation, with varying degrees of concomitant fibrosis. It predominantly affects the lungs, eyes, and skin. A transmissible cause has long been suspected based on epidemiologic studies, transmission via organ transplantation.
Sarcoidosis can affect any organ, although the lungs are involved in up to 95% of patients. Other organ systems commonly affected include the skin, eyes, and lymphoreticular system
The incidence of sarcoidosis has not changed during this time period. Findings suggest that more than 4000 new cases of sarcoidosis are currently diagnosed each year in the UK.