Intussusception is a serious disorder in which part of the intestine slides into an adjacent part of the intestine. This "telescoping" often blocks food or fluid from passing through. Intussusception also cuts off the blood supply to the part of the intestine that's affected. Intussusception can lead to a tear in the bowel (perforation), infection and death of bowel tissue. Intussusception is the most common cause of intestinal obstruction in children younger than 3.
Recent studies in the US, Australia and Mexico have found an increased risk of intussusception mainly following the first dose of rotavirus vaccines. Because intussusception risk varies across population and regions, and because some studies have shown high background rates of intussusception in Spain, we investigated this association in the Valencia Region, Spain. Retrospective self-controlled case series study among 98.3% of the Valencia Region infants aged 45-300 days during January 2007- December 2011. First intussusception episodes were identified from the Spanish hospital database (CMBD) using ICD-9-CM code 560.0, and confirmed by chart review using the Brighton Collaboration case definition Levels 1 and 2. Vaccination information was obtained from Valencia Region ́s vaccine information system (SIV). Vaccinated Cases Only (VCO) approach was performed using the date of diagnose as date of event, and both 1-7, and 1-21 risk periods, considering as observation period 42 days after first vaccine dose. Further analysis considering two risk periods (1-7 and 8-21) to compare the risk in different periods following vaccination were also analyzed.Incidence rate ratios (IRR) for first-dose were estimated.
An enema is the first step in treatment. In fact, an enema that is used to diagnose intussusception may also help to treat it. Pressure from the air or fluid may cause the intestine to correct itself. The result of an enema treatment might not last, so patients usually stay in the hospital overnight for observation. Surgery is another treatment option. Intussusception surgery involves either a large incision or a small incision and a camera. This is called laparoscopic surgery. The type of surgery depends on the location and severity of the obstruction. Intussusception surgery may include removal of the affected section of intestine. In the US, intussusception occurs in 18 to 56/100,000 infants, most commonly in infants between 5 and 6 months of age. Boys are more commonly affected than girls. Since 1980, rates of intussusception-related hospitalization and intussusception-related death have been decreasing. In the US, racial variation has been demonstrated, with white infants less commonly affected (26 to 35/100,000) than black infants (30 to 50/100,000) and infants of other races (112 to 240/100,000).