Multiple endocrine neoplasia(MEN-1) is also known as Wermer's syndrome. MEN-1 is a hereditory disorder .This type of hereditory disosorder generally passed from one generation to next generation. It affects the hormone producing glands.This disorder increases the development of tumors like cancerous and non cancerous tumors in glands.Non cancerous tumors may develop in parathyroid glands,Neuroendocrine system,anterior pituitory glands and skin. The symptoms are tiredness, bone pain, fractures and kidney stones, as well as stomach or intestinal ulcers.
At the end of the 1920s, the presence of the “classical” P-triad (Parathyroid, Pancreatic, and Pituitary adenomas) was reported in a patient.In 1953, a first review of related syndromes in 14 cases was published. Up to this period, the existence of the syndrome as a distinct clinical entity had not been assumed or suspected. In 1954, Wermer was the first to suggest that the P-triad could represent a trait inherited in an autosomal dominant manner with high penetrance. This insight is honored by also referring to MEN1 as Wermer syndrome.