Symptoms of the streptobacillary form include recurrent fever, chills, rash, and arthralgias. S. moniliformis is difficult to grow in culture and requires specific media and incubation conditions. Rat-bite fever is treated with antibiotics (penicillin or tetracyclines for 7-14 days). Erythromycin 500 milligrams might be administered to people who are allergic to penicillin. Doxycycline 100 milligrams every 12 hours for 14 days is an alternative form of treatment. People that handle rats or clean their cages should wear protective gloves, wash their hands after contact, and avoid hand-to mouth contact.