Sarcoidosis is a systemic disorder characterized by non-necrotizing granulomatous inflammation, with varying degrees of concomitant fibrosis. It predominantly affects the lungs, eyes, and skin. A transmissible cause has long been suspected based on epidemiologic studies, transmission via organ transplantation.
Sarcoidosis can affect any organ, although the lungs are involved in up to 95% of patients. Other organ systems commonly affected include the skin, eyes, and lymphoreticular system.
From 1988-2007, sarcoidosis-related mortality rates increased significantly, particularly in non-Hispanic black females aged 55 years or older. The underlying cause of death in most patients with sarcoidosis was the disease itself.