Definition: Small vessel disease is a condition in which the small arteries in the heart become narrowed. Small vessel disease causes signs and symptoms of heart disease, such as chest pain (angina). Small vessel disease is sometimes called coronary microvascular disease or small vessel heart disease. It's usually diagnosed after a doctor checks for blockages in the main arteries of the heart but finds little or no narrowing in the large vessels, even though your symptoms persist.
Symptoms: Chest pain, squeezing or discomfort, Chest pain associated with discomfort in your left arm or jaw, Chest pain that worsens with daily activities and at times of emotional stress, Neck, shoulder, upper back or abdominal discomfort, Shortness of breath, Unusual fatigue, A loss of energy, Trouble sleeping.
Statistics: Reduced QoL was associated with depression in patients with SVD, but this association was not mediated by disability or cognition; very similar results were found in the replication SVD cohort. In contrast, the non-SVD stroke group and the healthy older adult group showed a direct relationship between disability and depression. The DTI study showed that fractional anisotropy, a marker of white matter damage, was related to depressive symptoms in patients with SVD.