alexa Toxic Shock Syndrome | United States| PDF | PPT| Case Reports | Symptoms | Treatment

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Toxic Shock Syndrome

  • Toxic Shock Syndrome

    Toxic shock syndrome (TSS) is an acute life-threatening illness, usually caused by infection with either Staphylococcus aureus orStreptococcus pyogenes. The symptoms of TSS are a high fever, vomiting, diarrhea, a sunburn-like rash, red eyes, dizziness, lightheadedness, muscle aches and low blood pressure. In a severe case, TSS can cause kidney and liver failure – any of these symptoms requires immediate medical care. The annual incidence of staphylococcal TSS in the United States is 1-5 cases per 100,000 menstruating women. The annual incidence of streptococcal TSS is 5-10 cases per 100,000 individuals. Staphylococcal TSS is more common in females during menstruation. 

  • Toxic Shock Syndrome

    Patients with TSS must be treated immediately. In case of unconfirmed suspected TSS broad spectrum antibiotics like clindamycin+carbapenem/beta-lactamase inhibitor/vancomycin must be administered. Aggressive fluid management, ventilation, renal replacement therapy and inotropic support are essential as supportive care. The FDA recently approved 3 new antibiotics, oritavancin, dalbavancin, and tedizolid, for the treatment of acute bacterial skin infections. These agents are active against S. aureus, S. pyogenes, S. agalactiae, and S. anginosus group.

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