Urticaria results from the release of histamine, bradykinin, leukotriene C4, prostaglandin D2, and other vasoactive substances from mast cells and basophils in the dermis. These substances cause extravasation of fluid into the dermis, leading to the urticarial lesion. The intense pruritus of urticaria is a result of histamine released into the dermis.
Approx 1 in 6 or 15.00% or 40.8 million people in USA. Incidence (annual) of Hives is about 15% Americans each year (NWHIC).
Antihistamines are the most helpful. Over-the-counter antihistamines, such as Benadryl, are helpful, but often cause side effects, such as drowsiness. Some of the newer prescription antihistamines can help without causing any side effects.
Autoimmune Antibodies found in Urticaria and Treatment Projects currently undergoing include studies focusing on the autoimmune antibodies found in urticaria and treatment of urticaria with newer medications. The autoimmune antibody study aims at learning more about the biology of urticaria by studying the antibodies produced in some of the patients, and the receptors they bind to, on the skin cells.