Pathophysiology: Viral hemorrhagic fever (VHFs) is a general term to severe group of illness caused by RNA viruses from several viral families. It is a severe multisystem syndrome caused by infectious viruses which lead to a potentially lethal disease syndrome characterized by fever, malaise, vomiting, mucosal and gastrointestinal (GI) bleeding.VHF is caused by viruses of four families: arenaviruses, filoviruses, bunyaviruses, and flaviviruses.
Disease Statistics: Cases of viral hemorrhagic fever in the United States are extremely rare and usually are found in patients who recently have visited endemic areas or among those with potential occupational exposure to hemorrhagic fever viruses. No human cases of Ebola or Marburg virus disease have been reported in the United States. Estimated 100-200 cases of imported dengue fever are reported in the United States each year.
Treatment: Patients usually receive supportive therapy but as such there are no other treatment or established cure for VHFs. Ribavirin, an anti-viral drug, have been effective in treating some individuals with Lassa fever or HFRS. Treatment with convalescent-phase plasma has been used with success in some patients with Argentine hemorrhagic fever.
Research: Research groups involved universities of Colombia including University of Cordoba, Institute for Tropical Biological Research, School of Veterinary Medicine, University of Cartagena, Faculty of Economical Sciences, Research Group of Economics on Health, Cartagena and University children's hospital Napoleon Franco, Research and teaching division. Cartagena.