|It is a type of cardiovascular diseases which affects the blood vessels. It is a clinical condition of large and medium sized arteries which is affected by dysfunction of endothelial cell. Pathogens, cytokines, inflammatory stimuli endothelial cells are factors which causes vascular diseases. Once endothelial cells become activated it release cytokines and chemokines which expresses adhesion molecules on their surface which results in to release of WBC. WBC can infiltrate the blood vessels wall. Stimulation of smooth muscle layer with cytokine further causes thickening of vessel wall and at a final stage it results in to strokes.A journalÂ is aÂ periodical publicationÂ intended to further progress ofÂ science, usually by reporting newÂ research. Most journals are highly specialized, although some of the oldest journals publish articles, reviews, editorials, short communications, letters, andÂ scientific papersÂ across a wide range of scientific fields. Journals contain articles that peer reviewed, in an attempt to ensure that articles meet the journal's standards of quality, and scientificÂ validity. Each such journal article becomes part of the permanent scientific record.