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| Figure 8: 90% confidence intervals for dose-normalised artesunate and dihydroartemisinin pharmacokinetic parameters obtained after single oral doses of artesunate and mefloquine given as a Fixed formulation (200 mg artesunate/400 mg mefloquine) or a Non-fixed formulation (4 mg/ kg artesunate + 0 mg/kg mefloquine) to uncomplicated falciparum malaria patients and dose-normalised mefloquine pharmacokinetic parameters obtained after multiple oral doses of artesunate and mefloquine given as a Fixed formulation (200 mg artesunate/400 mg mefloquine daily for 3 days) or a Non-Fixed formulation (4 mg/kg artesunate + 0 mg/kg mefloquine on Day 1; 4 mg/kg artesunate + 15 mg/kg mefloquine on Day 2; 4 mg/kg artesunate + 10 mg/kg mefloquine on Day 3) to uncomplicated falciparum malaria patients. Data expressed as 90% confidence intervals around the ratio (% Fixed/Non-Fixed) of geometric least square means. |
