dihydroartemisinin and mefloquine pharmacokinetic

Parameter	Non-Fixed Formulation	Fixed Formulation
Artesunate
AUC_last (µg.hr/L)	419 ± 670	310 ± 324
C_max (µg/L)	451 ± 440	255 ± 272
T_max (hr)	0.925 ± 0.563 (0.750)	0.833 ± 0.702 (0.500)
Artesunate, Dose-Normalised to 200 mg Artesunate
Dose-Normalised AUC_last (µg.hr/L)	430 ± 707	310 ± 324
Dose-Normalised C_max (µg/L)	448 ± 381	255 ± 272 *
Dihydroartemisinin
AUC_last (µg.hr/L)	3633 ± 1367	3027 ± 2491
AUC_inf (µg.hr/L)	3745 ± 1371	3138 ± 2491
C_max (µg/L)	2043 ± 949	1234 ± 857
T_max (hr)	1.41 ± 0.714 (1.50)	1.99 ± 1.12 (2.00)
Dihydroartemisinin, Dose-Normalised to 200 mg Artesunate
Dose-Normalised AUC_last (µg.hr/L)	3695 ± 1424	3027 ± 2491
Dose-Normalised AUC_inf (µg.hr/L)	3812 ± 1443	3138 ± 2491
Dose-Normalised C_max (µg/L)	2059 ± 941	1234 ± 857 *
Mefloquine
AUC_last (µg.hr/L)	782607 ± 224234	810835 ± 364880
AUC_inf (µg.hr/L)	1062533 ± 365937	1149417 ± 758992
C_max (µg/L)	3239 ± 734	3279 ± 1252
T_max (hr)	70.9 ± 13.5 (72.0)	71.3 ± 17.3 (72.0)
Mefloquine, Dose-Normalised to 400 mg Mefloquine
Dose-Normalised AUC_last (µg.hr/L)	763147 ± 232259	810835 ± 364880
Dose-Normalised AUC_inf (µg.hr/L)	1029264 ± 351032	1149417 ± 758992
Dose-Normalised C_max (µg/L)	3184 ± 934	3279 ± 1252

*p < 0.05 compared to Non-Fixed formulation data; statistical analysis not conducted on non-dose-normalised data.

Table 3: Derived artesunate, dihydroartemisinin and mefloquine pharmacokinetic parameters for uncomplicated falciparum malaria patients administered artesunate and mefloquine as a Fixed formulation (200 mg artesunate/400 mg mefloquine daily for 3 days) or a Non-Fixed formulation (4 mg/kg artesunate + 0 mg/kg mefloquine on Day 1; 4 mg/kg artesunate + 15 mg/kg mefloquine on Day 2; 4 mg/kg artesunate + 10 mg/kg mefloquine on Day 3) (Fixed: n=20; Non-Fixed: n=23). Data expressed as mean ± standard deviation (median).

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