Parameters |
Test |
Reference |
P value |
|
P |
M |
P |
M |
P |
M |
AUC(0-t) ((µg h/mL))
AUC(0-∞) ((µg h/mL)) |
3.13 ± 1.03
4.70 ± 1.40 |
7.26 ± 3.72
28.50 ± 19.76 |
3.28 ± 1.08
5.02 ± 1.99 |
7.33 ± 4.04
26.40 ± 19.55 |
0.23
0.20 |
0.45
0.15 |
AUMC(0-t) ((µg h/mL)) |
17.58 ± 12.15 |
72.49 ± 68.89 |
19.98 ± 14.54 |
73.93 ± 72.51 |
0.20 |
0.46 |
Cmax (µg/mL) |
0.41 ± 0.07 |
0.85 ± 0.28 |
0.42 ± 0.06 |
0.90 ± 0.28 |
0.26 |
0.05 |
Tmax (h) |
0.90 ± 0.25 |
2.27 ± 0.49 |
1.04 ± 0.41 |
2.33 ± 0.38 |
0.08 |
0.31 |
t1/2 (h) |
7.13 ± 2.00 |
57.78 ± 47.04 |
8.40 ± 6.17 |
48.74 ± 36.17 |
0.16 |
0.11 |
MRT (h) |
10.94 ± 2.79 |
80.07 ± 65.43 |
12.54 ± 7.89 |
67.35 ± 50.59 |
0.16 |
0.11 |
P = Pioglitazone, M = Metformin, AUC = Area under curve, AUMC = Area under moment curve, Cmax = maximal plasma concentration, Tmax = time for the maximal plasma
concentration, t1/2 = Elimination half life, MRT = Mean residence time |
