subject after a single oral dose of 200 mg of Seroquel

Subject No.	C_max (ng/ml)	AUC_0-last (ng/ml)	AUC_0-α (ng/ml)	AUC extrapolated (%)	T_max (h)	T_1/2 (h)	Vd/F (L)	CL/F (L/h)
1	868.43	2861.14	2897.14	1.24	1.50	4.25	0.42	0.07
2	632.91	2738.75	2764.23	0.92	0.50	6.36	0.66	0.07
3	1060.34	2632.1	2650.97	0.71	0.50	3.42	0.370	0.08
4	554.54	1836.02	1846.72	0.58	0.50	3.60	0.56	0.11
5	351.58	1963.21	1971.87	0.44	1.50	5.29	0.77	0.10
6	393.3	2619.09	2621.57	0.10	0.50	4.64	0.51	0.08
7	523.55	1837.56	1857.16	1.06	0.75	3.70	0.58	0.11
8	868.32	3668.95	3687.59	0.51	2.00	2.92	0.23	0.05
9	887.34	3203.52	3218.99	0.48	0.75	3.02	0.27	0.06
10	631.48	1500.43	1508.78	0.55	0.75	6.07	1.16	0.13
11	1089.57	2658.70	2663.95	0.20	0.50	2.58	0.28	0.08
12	379.57	992.64	997.39	0.48	0.75	3.42	0.99	0.20
13	885.57	3173.09	3180.13	0.22	1.00	5.01	0.45	0.06
14	694.46	3103.81	3111.21	0.24	0.75	5.33	0.49	0.06
15	683.78	2766.5	2774.98	0.31	1.00	5.55	0.58	0.07
16	376.02	2316.01	2335.52	0.84	1.25	7.63	0.94	0.09
17	431.85	1742.22	1747.47	0.30	0.50	4.76	0.79	0.11
18	498.45	3713.2	3720.78	0.20	0.75	5.12	0.40	0.05
19	776.81	2673.57	2680.94	0.27	1.00	5.63	0.61	0.07
20	451.17	1755.85	1778.51	1.27	3.00	4.27	0.69	0.11
21	544.4	2763.70	2771.59	0.28	0.50	5.12	0.53	0.07
22	505.62	2301.01	2367.81	2.82	2.00	6.29	0.77	0.08
23	637.89	3471.6	3479.47	0.23	1.50	5.16	0.43	0.06
24	605.01	1991.04	1999.92	0.44	0.50	7.41	1.07	0.10
Mean	638.83	2511.82	2526.45	0.61	-	4.86	0.60	0.09
S.D.	214.49	704.21	704.37	0.58	-	1.35	0.25	0.03
Median	-	-	-	-	0.75	-	-	-
Max.	-	-	-	-	3.0	-	-	-
Min.	-	-	-	-	0.5	-	-	-

Table 1: Quetiapine pharmacokinetic parameters of individual subject after a single oral dose of 200 mg of Seroquel^®.

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