| |
|
Free IgE |
Total IgE |
| Formulation |
Statistics |
Cmin
(ng/ml) |
tmin
(day) |
Max % decrease
from screening |
Cmax
(ng/ml) |
tmax
(day) |
Max % increase
from screening |
Omalizumab solution
(n= 74) |
Mean ± SD
(CV%)
Range |
7.90 ± 4.06
(51.4)
1.00–21.30 |
2.0a
—
0.5–5.0 |
95.3 ± 3.0
(3.1)
86.7–99.1 |
1,176 ± 723
(61.5)
392–3,720 |
21.0a
—
7.0–84.0 |
490 ± 172
(35.2)
133–1,043 |
Omalizumab powder for solution
(n= 80) |
Mean ± SD
(CV%)
Range |
7.50 ± 4.18
(55.7)
1.95–21.30 |
2.0a
—
0.5 – 28.0 |
95.8 ± 2.7
(2.9)
85.0–99.3 |
1,136 ± 685
(60.3)
144–3,612 |
21.0a
—
10.0–84.0 |
446 ± 220
(49.4)
39–1,452 |
aMedian.
IgE = immunoglobulin E, Cmin = minimum serum concentration, tmin = time to Cmin, Cmax = maximum serum concentration, tmax = time to Cmax, mean = arithmetic mean, SD =
standard deviation, CV% = coefficient of variation. |
