Distributions of Simulated PK Parameters

*Parameter*	*Distribution*	*Mean*	*Intra-subject CV*	*Inter-subject CV*
Volume of Distribution, V	Normal	1L/kg	10%	10%
Clearence, CL	Normal	0.374L/(hr×kg)	10%	10%
k_αAbsorption rate constant, k_α	Normal	1.39hr‾	10%	10%
Bioavailability, F	Uniform	0.5	0.1 ±	0.1 ±

Table 1: Distributions of Simulated PK Parameters.

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