Tenofovir (N=39)

Lamivudine (N=39)

PK Parameter

Reference

arithmetic mean (SD)

Test

arithmetic mean (SD)

P value

Reference

arithmetic
mean (SD)

Test

arithmetic
mean (SD)

P value

C_max (ng/ml)

235.21       (68.66)

239.75
(81.07)

0.79

2538.80
(964.98)

2279.01
(756.76)

0.190

T_max (hours)

0.95
(0.55)

0.77
(0.32)

NA

1.73    
 (0.69)

1.41
(0.55)

NA

AUC_last (ng*h/ml)

1679.53 (783.72)

1592.46 (686.98)

0.603

10954.77
(2417.68)

10647.98
(2399.37)

0.575

AUC_inf (ng*h/ml)

2043.68 (944.63)

1894.78 (783.35)

0.451

11300.91
(2585.9)

10979.83
(2543.85)

0.582

 Ke  (1/h)

0.05
(0.02)

0.05
(0.02)

1.00

0.13
(0.08)

0.14
 (0.07)

0.558

Terminal half-life (h)

17.07
(7.20)

16.42
 (6.70)

0.681

6.99
(4.12)

6.33
(3.49)

0.447