Parameters |
Units |
Formulations |
P-value |
Flonicol®
(Test) |
Veterin®10% (Reference) |
Cmax |
µg/ml |
9.02±0.68 |
9.20±0.77 |
0.839 |
tmax |
h |
1.02±0.13 |
1.05±0.30 |
0.899 |
t1/2β |
h |
1.41±0.06 |
1.35±0.05 |
0.407 |
AUC0-12h |
µg.h/ml |
26.45±1.33 |
26.06±1.20 |
0.803 |
AUC0-∞ |
µg.h/ml |
26.61±1.33 |
26.26±1.21 |
0.821 |
AUMC |
µg.h2/ml |
71.78±4.65 |
69.98±8.80 |
0.832 |
MRT |
h |
2.72±0.18 |
02.62±0.27 |
0.723 |
ClB/F |
ml\min\kg |
12.82±0.63 |
12.96±0.60 |
0.844 |
Vdz/F |
l\kg |
1.55±0.08 |
1.51±0.08 |
0.692 |
Cmax, maximum plasma concentration; tmax, time to peak concentration; t1/2β,
elimination half-life; AUC0-12h, area under plasma concentration-time curve from
zero to 12h post drug administration; AUC0-∞, area under plasma concentrationtime
curve from zero to infinity; AUMC, area under the first moment timeconcentration
curve; MRT, mean residence time; F, systemic bioavailability;
ClB/F, total body clearance/F; Vdz/F, volume of distribution/F. |
