| Study # |
Test Article |
Formulation |
Route |
Dose (mg/kg) |
Cmax (ng/mL) |
Tmax (hr) |
T1/2 (hr) |
AUClast (hr*ng/mL) |
CL (ml/hr/kg) |
Vss (mL/kg) |
F (%) |
| Study 1 |
[I-125]Peptide A |
IR |
IV |
0.5 |
9638 ± 403 |
NA |
2.9 ± 2.2 |
15757 ± 2628 |
30 ± 6 |
68 ± 15 |
NA |
| Study 2 |
Peptide A |
IR |
SC |
2 |
1835 ± 528 |
1.3 ± 0.6 |
4.7a |
9653±4093 |
NA |
NA |
15 |
| Study 3 |
Peptide A |
CR |
SC |
2 |
9638 ± 403 |
10 ± 12 |
10a |
5506 ± 1144 |
NA |
NA |
8.7358 |
aN=1, t1/2 was not able to be determined from other two animals due to an incomplete PK profile. F% (bioavailability) is calculated by (AUClast, SC/Dose,SC)/(AUClast, IV/Dose,IV) |
