| Product A |
| Parameters |
Arithmetic Mean
mean [SD] |
Range |
| AUC0-∞ (ng*min/mL) |
1719.93 [918.47] |
761.49-3167.70 |
| Cmax (ng/mL) |
17.2 [9.3] |
7.4-37.4 |
| Tmax (min) |
42.5 [24.9] |
20.0-90.0 |
| T1/2(min) |
54.0 [9.6] |
45.3-75.6 |
| Ka (min-1) |
0.0311 [0.0188] |
0.0127-0.0656 |
| MRT (min) |
57.2 [18.2] |
32.0-86.3 |
| Product B |
| AUC0-∞ (ng*min/mL) |
1179.23 [776.80] |
232.84-2579.90 |
| Cmax (ng/mL) |
12.4 [6.6] |
3.6-22.9 |
| Tmax (min) |
37.5 [11.7] |
20.0-60.0 |
| T1/2(min) |
51.9 [13.4] |
34.0-69.1 |
| Ka (min-1) |
0.0438 [0.0560] |
0.0176-0.1820 |
| MRT (min) |
51.6 [13.8] |
33.4-72.9 |
| Ratio A/B |
| Variable |
mean [SD] |
Range |
| AUC0-∞ (ng*min/mL) |
1.86 [1.17] |
0.87-4.07 |
| Cmax (ng/mL) |
1.5 [0.5] |
0.9-2.5 |
|
