| Pharmacokinetic Parameter |
Combination Tablets
(2×Azithromycin 250 mg/
Chloroquine 155 mg)
(n=20) |
Individual Tablets
(Azithromycin 500 mg+Chloroquine 300 mg)
(n=20) |
| Azithromycin |
| AUClasta (ng•h/mL) |
3910 (30) |
3877 (32) |
| Cmaxa (ng/mL) |
496 (40) |
437 (38) |
| Tmaxb (h) |
1.00 (0.50–2.00) |
1.52 (0.50–3.00) |
| Chloroquine |
| AUClasta (ng•h/mL) |
3252 (35) |
3280 (30) |
| Cmaxa (ng/mL) |
95.8 (36) |
108 (34) |
| Tmaxb (h) |
1.01 (1.00–6.00) |
2.00 (0.50–12.00) |
AUClast=area under the drug concentration–time profile from time zero to the time of last quantifiable concentration Cmax=maximum concentration, Tmax=time to maximum concentration, aGeometric mean (CV%), bMedian (range). |
