Media Makoid-Banakar Formulation ER tablet 70 mg (T) Preductal® MR 35 mg (R) weighing Function R2 Weighted R2 AIC SBC R2 Weighted R2 AIC SBC 0.1 N HCl uniform 0.9991 0.9991 -58.601 -57.995 0.9993 0.9993 -53.219 -52.825 1/yhat*yhat 0.9986 0.9983 -38.026 -37.633 0.9988 0.9995 -41.812 -41.653 pH 4.5 AB uniform 0.9971 0.9971 -49.874 -49.269 0.9998 0.9998 -66.768 -66.374 1/yhat*yhat 0.9951 0.9978 -39.277 -38.883 0.9994 0.9996 -53.864 -53.705 pH 6.8 PB uniform 0.9971 0.9971 -49.527 -48.922 0.9957 0.9957 -39.955 -39.56 1/yhat*yhat 0.9952 0.9981 -39.482 -39.088 0.9875 0.9865 -26.239 -26.08 Water uniform 0.9963 0.9963 -47.77 -47.165 0.9991 0.9991 -50.307 -49.913 1/yhat*yhat 0.9941 0.9979 -38.574 -38.18 0.9981 0.9991 -43.715 -43.556

Table 3: Summary of model parameters and selection of mean in vitro dissolution profile of Trimetazidine dihydrochloride extended release tablet.

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