| Body System |
Desvenlafaxine |
Venlafaxine |
Placebo |
| |
150 mg
(n=6) |
225 mg
(n=6) |
300 mg
(n=6) |
450 mg
(n=6) |
600 mg
(n=6) |
750 mg
(n=5) |
750 mg
fasted
(n=6) |
900 mg
(n=6) |
150 mg
( n=16) |
(n=16) |
| Any adverse event |
2 (33) |
2 (33) |
2 (33) |
2 (33) |
0 |
5 (100) |
4 (67) |
5 (83) |
5 (31) |
1 (6) |
Digestive
Nausea
Nausea (severe)
Vomiting |
1 (17)
0
0 |
2 (33)
0
0 |
2 (33)
0
0 |
2 (33)
0
0 |
0
0
0 |
5 (100)
0
2 (40) |
3 (50)
1 (17)
1 (17) |
5 (83)
2 (33)
4 (67) |
4 (25)
1 (6)
1 (6) |
0
0
0 |
Nervous
Dizziness
Feeling drunk
Paresthesia |
1 (17)
1 (17)
0 |
0
0
0 |
0
0
0 |
0
0
0 |
0
0
0 |
0
0
2 (40) |
2 (33)
1 (17)
0 |
0
2 (33)
0 |
0
0
0 |
0
0
0 |
Respiratory
Yawn |
0 |
0 |
0 |
0 |
0 |
2 (40) |
0 |
0 |
0 |
0 |
Skin/appendages
Sweating |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
2 (33) |
0 |
0 |
|
