| Parameters |
Units |
Enromic® 20% |
| Enrofloxacin |
Ciprofloxacin |
| Cmax |
µg mL-1 |
1.319 ± 0.320 |
0.047 ± 0.010 |
| Tmax |
h |
3.500 ± 1.581 |
9.200 ± 1.932 |
| λZ |
h-1 |
0.077 ± 0.018 |
0.044 ± 0.005 |
| AUC0→t |
µg h mL-1 |
17.640 ± 3.041 |
1.004 ± 0.137 |
| AUC0→∞ |
µg h mL-1 |
17.821 ± 3.020 |
1.027 ± 0.138 |
| AUMC |
µg h2 mL-1 |
235.005 ± 63.683 |
19.665 ± 3.402 |
| MRT |
h |
13.087 ± 1.778 |
17.283 ± 1.785 |
| t1/2,z |
h |
9.487 ± 2.118 |
15.990 ± 1.856 |
| Vd/F |
L Kg-1 |
5.601 ± 0.970 |
|
| CLS/F |
L Kg-1 h-1 |
0.430 ± 0.063 |
|
Cmax: Maximum concentration in pigs plasma; Tmax: Time when maximum concentration was obtained. AUC0→t: Area under the concentration-time curve from the time zero to 77 h; AUC0→∞: Area under the concentration-time curve from the time zero to infinity in pigs plasma; AUMC: Area under the first moment concentration-time curve; MRT: Mean residue time of drug in body; λZ : Terminal slope of the drug concentration-time curve; t1/2,z: Half-life of the drug; CLs/F : Total body clearance; Vd/F: Apparent volume of distribution. |
