|
Cmax, ng/mL |
tmax, ha |
AUCT, ng.h/mL |
AUC, ng.h/mL |
t1/2, h |
Cl/F, L/h/kg |
Vz/F, L/kg |
CLR, L/h/kg |
Recovery, unconj. (%) |
Recovery, total (%) |
Desvenlafaxine 400 mg |
|
|
|
Mean (SD) |
819 (161) |
6.00 |
21784 (4310) |
21942 (4321) |
9.79 (0.98) |
0.26 (0.05) |
3.59 (0.63) |
0.117 (0.035) |
46 (13) |
63 (15) |
%CV |
19.7 |
|
19.8 |
19.7 |
10.0 |
17.8 |
17.6 |
30.0 |
27.5 |
23.3 |
Geometric mean |
804 |
|
21398 |
21557 |
9.75 |
0.25 |
3.54 |
0.111 |
44 |
61 |
Min, Max |
562, 1105 |
4.00, 16.03 |
15568, 31485 |
15607, 31654 |
8.14, 11.36 |
0.17, 0.33 |
2.71, 4.78 |
0.049, 0.165 |
25, 68 |
34, 78 |
Desvenlafaxine 400 mg + ketoconazole 200 mg |
|
|
|
Mean (SD) |
884 (185) |
8.00 |
30820 (6260) |
31245 (6463) |
13.49 (1.47) |
0.18 (0.03) |
3.50 (0.60) |
0.092 (0.017) |
51 (8) |
68 (9) |
%CV |
21.0 |
|
20.3 |
20.7 |
10.9 |
18.3 |
17.1 |
19.0 |
15.2 |
13.1 |
Geometric mean |
865 |
|
30301 |
30702 |
13.42 |
0.18 |
3.45 |
0.090 |
50 |
68 |
Min, Max |
631, 1192 |
4.00, 16.00 |
23914, 47640 |
24079, 48697 |
10.94, 16.20 |
0.11, 0.23 |
2.32, 4.85 |
0.061, 0.124 |
37, 65 |
44, 77 |
CV: coefficient of variation; Max: maximum; Min: minimum
aMedian data are presented for tmax |
