|
Cmax, ng/mL |
tmax, ha |
AUCT, ng.h/mL |
AUC, ng.h/mL |
t1/2, h |
Midazolam 4 mg |
Midazolam |
|
|
|
|
|
Mean (SD) |
22.29 (7.12) |
0.52 |
56.50 (23.98) |
58.77 (26.67) |
5.32 (1.59) |
%CV |
32 |
|
42 |
45 |
30 |
Geometric mean |
21.20 |
|
52.85 |
54.69 |
|
Min, Max |
7.86, 44.3 |
0.25, 1.50 |
26.6, 149 |
27.4, 166 |
2.55, 8.62 |
1'-Hydroxymidazolam |
|
|
|
|
|
Mean (SD) |
16.25 (6.53) |
1.00 |
42.75 (25.37) |
43.30 (28.23) |
5.40 (2.06) |
%CV |
40 |
|
59 |
65 |
38 |
Geometric mean |
14.93 |
|
37.09 |
36.87 |
|
Min, Max |
5.22, 28.0 |
0.25, 1.50 |
11.4, 132 |
12.0, 138 |
2.62, 11.0 |
Midazolam 4 mg + desvenlafaxine 400 mg |
Midazolam |
|
|
|
|
|
Mean (SD) |
18.92 (5.11) |
0.50 |
39.83 (12.52) |
41.33 (13.30) |
4.65 (1.74) |
%CV |
27 |
|
31 |
32 |
38 |
Geometric mean |
18.24 |
|
38.11 |
39.45 |
|
Min, Max |
9.52, 29.2 |
0.25, 1.02 |
22.6, 72.3 |
23.9, 73.5 |
2.12, 7.99 |
1'-Hydroxymidazolam |
|
|
|
|
|
Mean (SD) |
16.21 (6.25) |
0.50 |
35.24 (14.88) |
33.43 (14.65) |
4.62 (1.80) |
%CV |
39 |
|
42 |
44 |
39 |
Geometric mean |
15.10 |
|
32.42 |
30.74 |
|
Min, Max |
7.27, 28.7 |
0.25, 1.02 |
14.8, 68.0 |
15.4, 61.6 |
2.66, 9.89 |
aMedian data are presented for tmax |
