Midazolam n=26

Desvenlafaxine Titration n=25

Desvenlafaxine + Midazolam n=24

Desvenlafaxine Taper n=24

Any adverse event, n (%)

4 (15.4)

12 (48.0)

2 (8.3)

2 (8.3)

Urinary hesitation

2 (7.7)

0

0

0

Constipation

1 (3.8)

3 (12.0)

1 (4.2)

1 (4.2)

Headache

1 (3.8)

3 (12.0)

1 (4.2)

0

Asthenia

0

3 (12.0)

0

0

Diarrhea

0

2 (8.0)

0

0

Dizziness

0

2 (8.0)

0

0

Dry mouth

0

2 (8.0)

0

0

Nausea

0

2 (8.0)

0

0

Somnolence

0

2 (8.0)

0

0

Trismus

0

2 (8.0)

0

0

Table 5: Treatment-emergent adverse events observed in ≥ 2 subjects during study 2.
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