Parameters
C
1
(1.28 mg/kg)
C
1a
(1.65 mg/kg)
C
2
(0.98 mg/kg)
C
2a
(1.10 mg/kg)
Total (5.00 mg/kg)
t
1/2
b
(h)
1.69 ± 0.56
a
6.45 ± 1.12
b
3.87 ± 0.62
b
5.24 ± 0.90
b
4.00 ± 0.49b
MRT
(h)
1.66 ± 0.44
a
6.76 ± 1.05
b
4.02 ± 0.41
b
6.05 ± 0.77
b
3.37 ± 0.36
b
Vd
area
(ml/kg)
193.64
a
± 0.45
741.74
b
± 0.96
629.55
b
± 0.47
627.66
b
± 0.86
557.80
b
± 0.41
V
ss
(ml/kg)
132.42
a
± 0.50
539.15
b
± 0.87
453.50
b
± 0.42
502.70
b
± 0.70
325.06
b
± 0.43
CL
B
(ml/hr/kg)
79.60 ± 0.56
79.76 ± 0.49
112.73 ± 0.39
83.10 ± 0.46
96.35 ± 0.30
AUC
0-∞
/Dose
(mg.h.kg/ml/mg)
12.57 ± 0.56
12.54 ± 0.49
8.86 ± 0.39
12.04 ± 0.46
10.38 ± 0.30
Extrapolated AUC
(%)
5 ± 0.66
31 ± 0.65
10 ± 0.45
25 ± 0.73
5 ± 0.69
a,b
Different superscripts indicate statistically significant differences
Table 1:
The pharmacokinetics parameters of gentamicin C
1a
, C
2a
, C
1
, C
2
and total gentamicin following single IV administration. Values are geometric mean ± SE of the log-transformed data (n=10).
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