|
Parameter (Units) |
Alprazolam 1 mg SL
(Test Treatment)
N=28 |
Alprazolam 1 mg IR (Reference Treatment)
N=28 |
| AUCinf (ng*hour/mL) |
| Geometric Mean (%CV) |
274.1 (38) |
286.3 (31) |
| Ratio of Adjusted Means (90% CI) |
95.75 (91.96, 99.69) |
| Arithmetic Mean (SD) |
289.7 (110.6) |
299.1 (92.6) |
| AUC(0–t) (ng*hour/mL) |
| Geometric Mean (%CV) |
259.5 (33) |
271.9 (29) |
| Ratio of Adjusted Means (90% CI) |
95.43 (91.74, 99.27) |
| Arithmetic Mean (SD) |
271.1 (88.1) |
282.9 (81.3) |
| Cmax (ng/mL) |
| Geometric Mean (%CV) |
15.2 (18) |
17.2 (19) |
| Ratio of Adjusted Means (90% CI) |
88.27 (83.68, 93.11) |
| Arithmetic Mean (SD) |
15.4 (2.8) |
17.5 (3.4) |
| Tmax (hour) |
| Median (range) |
2.00 (0.500-3.50) |
0.892 (0.500-2.50) |
| t1/2 (hour) |
| Arithmetic mean (SD) |
15.3 (4.6) |
15.2 (3.5) |
%CV: Percent Coefficients of Variation; IR: Immediate Release; SL: Sublingual; CI: Confidence Interval |
