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| Table 4: Comparison of the time to achieve the minimum effective plasma concentration (Cper) of valproic acid (20ug/mL defined arbitrary as 20ug/mL, see text), the time in which the plasma concentrations decay below Cper, and the total duration above Cper plasma concentrations (Tem), during the 24 hour period of observation after the single dose intake of two enteric coated tablets of 500mg sodium divalproate, by 24 healthy men participating in a cross-over study. All figures are given in hours (mean and SD; * significant). |
