Drug administration T or R* Histamine challenge Anterior rhinomanometry Day 01     Basal     X 00:00       00:15       00:30       00:60   X       X     Day 02 X     Day 03 X     Day 04 X       X     Day 05 X     Day 06 X     Day 07 X     Day 08     00:00     X         00:15       00:30       00:60     Washout 21 days   T: Drug-test; R: Drug-reference;

Table 1: Schedule of nasal challenge, rhinomanometric evaluation and drug administration

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