Name of the
Compounds
Porcine brain lipid (PBL) Papp (10
-6
Cm/S) (Mean±SEM)
Phosphatidylcholine Lipid P
app
(10
-6
Cm/S)
(Mean± SEM)
2 hours
5 hours
8 hours
16 hours
24 hours
2 hours
5 hours
8 hours
16 hours
24 hours
Olanzapine
18.40±
0.10
30.76 ±
0.78
30.11 ±
0.41
30.02 ±
0.43
30.86 ±
1.0
19.43 ±
0.20
27.77 ±
1.3
27.29 ±
0.38
27.64 ±
2.02
27.66 ±
0.39
Duloxetine
19.91 ±
0.00
28.33 ±
0.36
28.16 ±
1.30
28.00 ±
3.3
28.62 ±
1.3
17.23 ±
0.34
31.44 ±
0.68
30.04 ±
1.43
30.42 ±
0.25
30.87 ±
1.4
Carbamazepine
16.52 ±
0.3
25.32 ±
0.12
25.19 ±
0.49
24.95 ±
0.17
24.64 ±
0.6
8.24 ±
0.05
14.97 ±
0.42
14.94 ±
0.10
14.32 ±
0.15
14.99 ±
0.13
Diphenhydramine
14.55 ±
1.8
22.78 ±
0.04
22.20 ±
0.79
22.08 ±
1.4
22.31 ±
0.04
11.6 ±
0.009
17.96 ±
1.63
18.06 ±
0.23
17.86 ±
1.17
18.17 ±
1.39
Desipramine
13.07 ±
0.53
20.88 ±
0.21
20.34 ±
0.32
21.9 ±
0.41
21.95 ±
0.28
16.53 ±
0.12
23.63 ±
0.42
22.71 ±
0.23
22.86 ±
1.98
22.53 ±
0.66
Diazepam
11.93 ±
1.9
20.76 ±
0.63
20.88 ±
0.19
20.59 ±
0.5
20.35 ±
0.37
12.93 ±
0.22
20.04 ±
1.55
19.40 ±
0.57
20.8 ±
0.64
20.49 ±
0.39
Alprazolam
7.35 ±
0.48
11.81 ±
0.32
11.34 ±
0.25
11.17 ±
0.19
11.5 ±
0.20
6.25 ±
0.54
8.65 ±
0.54
8.30 ±
0.44
8.88 ±
0.53
8.16 ±
0.24
Imipramine
8.24 ±
0.65
12.34 ±
0.15
12.41 ±
0.60
12.04 ±
0.17
12.09 ±
0.17
7.23 ±
0.19
11.93 ±
0.32
11.21 ±
0.29
11.72 ±
0.31
10.81 ±
0.08
Promazine
5.14 ±
0.29
8.97 ±
0.13
9.05 ±
0.16
8.64 ±
0.17
8.86 ±
0.15
5.07 ±
0.10
8.77 ±
0.23
8.76 ±
0.53
8.71 ±
0.22
8.54 ±
0.12
Caffeine
2.98 ±
0.06
4.73 ±
0.09
5.13 ±
0.01
4.83 ±
0.05
4.98 ±
0.05
2.65 ±
0.10
4.87 ±
0.07
4.94 ±
0.06
4.93 ±
0.11
4.73 ±
0.02
Amitriphyline
3.16 ±
0.08
5.03 ±
0.18
4.84 ±
0.02
4.91 ±
0.04
4.95 ±
0.02
2.29 ±
0.13
4.51 ±
0.11
4.27 ±
0.07
4.40 ±
0.06
4.31 ±
0.06
Chlorpromazine
1.32 ±
0.003
2.92 ±
0.06
3.00 ±
0.03
2.96 ±
0.04
2.81 ±
0.04
1.26 ±
0.16
2.22 ±
0.06
2.40 ±
0.02
2.18 ±
0.05
2.12 ±
0.02
Dopamine
1.02 ±
0.07
1.03 ±
0.09
0.98 ±
0.02
1.07 ±
0.07
1.04 ±
0.05
1.30 ±
0.30
1.38 ±
0.10
1.30 ±
0.01
1.35 ±
0.07
1.32 ±
0.06
Atenolol
0.86 ±
0.02
0.97 ±
0.17
0.98 ±
0.00
0.95 ±
0.05
0.97 ±
0.04
0.92 ±
0.003
1.08 ±
0.01
0.99 ±
0.12
1.01 ±
0.08
0.98 ±
0.03
Ofloxacin
0.73 ±
0.05
0.72 ±
0.02
0.73 ±
0.02
0.71 ±
0.024
0.71 ±
0.01
0.11 ±
0.03
0.10 ±
0.03
0.13 ±
0.34
0.10 ±
0.00
0.11 ±
0.00
Norfloxacin
0.44 ±
0.01
0.39 ±
0.10
0.42 ±
0.02
0.39 ±
0.013
0.41 ±
0.02
0.26 ±
0.00
0.28 ±
0.03
0.30 ±
0.02
0.29 ±
0.01
0.31 ±
0.02
Table 3:
Average apparent permeability (P
app
) value at different incubation times.
Goto home»
