Drug Target Disease PK PD Docetaxel non-small-cell lung cancer cumulative AUC survival time Quetiapine schizophrenia plasma concentration BPRS Naratriptan migraine effect compartment concentration migraine improvement rate Ivabradine angina pectoris effect compartment concentration blood pressure, heart rate Pregabalin neuropathic pain plasma concentration (average) pain score Ibandronate osteoporosis DODR uCTX Gliclazide diabetes AUC fasting plasma glucose BPRS : Brief Psychiatric Rating Scale Scores DODR : Dose-Driving Rate uCTX : urine and urinary excretion of the C-telopeptide of the α chain of type I collagen

Table 1: Typical examples include pharmacokinetic (PK) - pharmacodynamic (PD) modeling and simulation in non-antimicrobial agents [21].

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