Kinetic parameters Healthy Mastitic P value C°p (μg/ml) 15.51 ± 1.41 12.48 ± 1.36 0.11 NS t1/2β(h) 4.04 ± 0.24 5.08 ± 0.18 0.01* Vdarea(L/kg) 1.89 ± 0.18 2.56 ± 0.21 0.05 NS AUC(mg/L.h) 33.68 ± 5.11 29.62 ± 2.18 0.052 NS MRT(h) 5.61 ± 0.49 7.77 ± 0.28 0.01** ClB(ml/kg/min) 5.64 ± 0.78 5.82 ± 0.44 0.86NS K12(h-1) 2.44 ± 0.70 6.24 ± 1.35 0.05* K21(h-1) 2.83 ± 0.97 3.59 ± 0.59 0.55 NS K2(h-1) 0.37 ± 0.05 0.39 ± 0.04 0.76 NS T/P ratio 1.05 ± 0.17 1.77 ± 0.28 0.07 NS NS = Non significant; *P < 0.05; **P < 0.01. C°p (μg/ml) = Zer-time plasma concentration; t1/2α(h) = Distribution plasma halflife; t1/2β(h) = Elimination plasma half-life; Vdarea = Volume of distribution based on area under curve; AUC = Area under curve; ClB = Total body clearance rate; K12 = Rate constant for transfer of drug from central to peripheral compartment; K21 = Rate constant for transfer of drug from peripheral to central compartment; K2= elimination from central compartment; MRT = Mean residence time; T/P ratio = Tissue to plasma ratio.

Table 1: Kinetic profile (Mean ± SE) of LVX (10 mg/kg, i.v.) in Plasma of healthy and mastitic goats.

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