PK Parameter |
Piperacillin (Mean ± SD ) |
Ceftazidime (Mean ± SD ) |
This study |
Occhipinti et al. [15] |
This study |
Lüthy et al. [16] |
t1/2 (h) |
3.1 ± 1.3 |
0.8 ± 0.1 |
17.6 ± 16.6 |
1.9 ± 0.2 |
Vd (L) |
22.2 ± 11.2 |
10.5 ± 1.4 |
13.5 ± 5.6 |
14.7 ± 1.4 |
CL (mL•min-1) |
95.2 ± 15.1 |
182.0 ± 20.0 |
24.7 ± 34.5 |
116.0 ± 18.0 |
SD, standard deviation; t1/2, elimination half-time;
Vd, volume of distribution; CL, total drug clearance |
