Route of administration

Oral

Formulation 1

Formulation 2

Intravenous

Dose (mg/kg)

50

50

10

AUC^(0-t)(µg.hr/mL)

5.87 ± 0.24

11.61 ± 0.28

7.50 ± 0.94

C_max/C₀(µg/mL)

1.31 ± 0.06

1.0 ± 0.12

5.29 ± 1.41

T_max(hr)

3.00

2.00

-

Kel  (1/hr)

-

-

0.62 ± 0.10

t_1/2( hr)

-

-

1.14 ± 0.20

V_d(lit)

-

-

1.99 ± 0.49

Cl(ml/kg/min)

-

-

22.48 ± 0.16

bioavailability (%)

16.7

33.02