autoimmune disease therapy

Helminths	Effect of infection or injection	Ref.
Nematode
Ancylostoma caninum	Inhibition of TNBS-induced colitis in mice by injecting A. caninum antigens	[9]
Ascaris suum	Chronic infection reduces eye disease in mice	[10]
Trichinella spiralis	Prevention of colitis in C57BL/6 mice	[11]
Strongyloides stercoralis	Suppression of pulmonary allergy in BALB/c mice	[12]
Heligmosomoides polygyrus	Inhibition of autoimmune type 1 diabetes in NOD mice	[13]
Heligmosomoides polygyrus	Protection from colitis in C57BL/6	[27,28]
Platyhelminth
Schistosoma mansoni	Inhibition of TNBS-induced colitis in mice by injecting S. mansoni antigens	[9]
	Inhibition of autoimmune type 1 diabetes in NOD mice	[13]
	Inhibition of type 1 diabetes in NOD mice by injecting S. mansoni antigens	[14]
	Prevention of DSS-induced colitis in BALB/c mice	[15]
	Suppression of collagen-induced arthritis in mice	[16]
Schistosoma japonicum	Inhibition of asthma development in BALB/c mice by injecting the egg antigens	[17]
Schistosoma japonicum	Protective effects for arthritis in DBA/1 mice	[18]

DSS, dextran sodium sulphate; NOD, Non-obese diabetic; DNBS, dinitrobenzene sulfonic acid; TNBS, trinitrobenzene sulfonic acid

Table 1: Examples of helminth parasites in animal models for inflammatory and autoimmune disease therapy.

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