PK Parameter
Piperacillin (Mean ± SD )
Ceftazidime (Mean ± SD )
This study
Occhipinti et al. [15]
This study
Lüthy et al. [16]
t
1/2
(h)
3.1 ± 1.3
0.8 ± 0.1
17.6 ± 16.6
1.9 ± 0.2
Vd (L)
22.2 ± 11.2
10.5 ± 1.4
13.5 ± 5.6
14.7 ± 1.4
CL (mL･min-1)
95.2 ± 15.1
182.0 ± 20.0
24.7 ± 34.5
116.0 ± 18.0
SD, standard deviation; t
1/2
, elimination half-time;
Vd, volume of distribution; CL, total drug clearance
Table 2:
Comparison of piperacillin and ceftazidime pharmacokinetic parameters in this study versus published data for healthy volunteers.
Goto home»
