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| Figure 1: a. The VSV glycoprotein after processing in the “Protein preparation wizard” of Glide. Color code for the different domains are: Domain I –Red, Domain II –Blue, Domain III -Orange and Domain IV –Yellow. (b to f): Predicted binding pockets in the VSV G protein trimer using Glide. The pockets are represented in blue/red mesh wire within the protein. The 3 monomeric units are shown in different colours, Chain A- green, Chain B- grey and Chain C- Red. b. Site 1: Spans all 3 monomers and encompasses regions in domain II and domain III. c. Site 2: domain II and domain III of chain A and chain C. d. Site 3: domain II and domain III of chain A and chain B. e. Site 4: domain II and domain III of chain B. f. Site 5: domain II and domain III of chain B. |
