| Drugs
Clones |
Amprenavir
(2.2)* |
Atazanavir
(2.1)* |
Darunavir
(2)* |
Indinavir
(2.3)* |
Lopinavir
(1.6)* |
Nelfinavir
(2.2)* |
Saquinavir
(1.8)* |
| |
IC50 |
FC |
IC50 |
FC |
IC50 |
FC |
IC50 |
FC |
IC50 |
FC |
IC50 |
FC |
IC50 |
FC |
| CRF02_AGWT_10L |
0.0199
±
0.0014 |
0.95 |
0.0072
±
0.0009 |
0.96 |
0.0039
±
0.0005 |
1.2 |
0.0134
±
0.0035 |
0.71 |
0.0292
±
0.0030 |
1.3 |
0.0147
±
0.0060 |
1.5 |
0.011 ± 0.0007 |
1.1 |
| HXB2 |
0.02100
±
0.0008 |
- |
0.0075
±
0.0005 |
- |
0.0031
±
0.0001 |
- |
0.0188
±
0.0015 |
- |
0.0223
±
0.0032 |
- |
0.0097
±
0.0022 |
- |
0.0098
±
0.0004 |
- |
*Fold-change (FC) biological cut-off determined for each PI by Antivirogram-Virco. IC50 values represent the average of two experiments in duplicate. For each drugs,
five different concentrations were used. Susceptibility of drugs has been determined by the fold change (FC) and calculated as the IC50 ratio of CRF02_AGWT_10L/
subtype B reference virus HXB2. |
