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| Figure 4: Dose-dependent effect curves of GRFT/HIV enzyme inhibitors (e.g. reverse transcriptase, integrase and protease) combinations in T cell-T cell HIV transmission. The dose response curves of GRFTin combination with the reverse transcriptase inhibitor tenofovir (A), the integrase inhibitor raltegravir (B) and the protease inhibitor saquinavir (C) are shown. The black lines show the dose-dependent effects of GRFT on giant cell formation. The green lines show each HIV enzyme inhibitor and the red lines show the effect of the two-drug combinations. Mean ± SEM up to 3 independent experiments are shown. |
