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| Figure 6: Effect of GRFT/antiretroviral drug combinations on the antiviral potency evaluated in the DC-SIGN mediated HIV transmission pathway. (A) Dosedependent anti-HIV effects of GRFT and the entry inhibitors 2G12 mAb (left panel) and T20 (right panel), alone and in combination in the DC-SIGN pathway. (B) Dose-dependent effects of tenofovir (left), raltegravir (middle) and saquinavir (right panel) on HIV replication and transmission alone and in combination with GRFT. Mean values ± SEM out of 3 independent experiments, performed in duplicate are shown. |
