Table 2 | Amino acid alterations in HIV-1 variants selected ..

		HIV-1 passaged with muparfostat			HIV-1 passaged without muparfostat
Passage no.	Day	Muparfostat concentration (μg/mL)	Amino acid change in gp120	Amino acid change in gp41	Amino acid change in gp120	Amino acid change in gp41
0	0	12,5	wt^a	wt	wt	wt
1	7	12,5
12	85	12,5	I152V^b	wt	K276R^b	wt
14	99	12,5
15	106	25
16	113	25	I152V^b	wt	K276R^b	wt
19	134	25
20	141	50
21	148	50	I152V K276R	L33S A101T	wt	I69V A300T
22	155	100
24	162	100	I152V K276R Δ366FNSTW370	L33S A101T	wt	I69V A300T

^aAmino acid sequence of the original wild type (wt) virus HIV-1^IIIB
^bConfers to partial amino acid substitution with the wild type background

Table 2: Amino acid alterations in HIV-1 variants selected by virus passaging in H9 cells in presence of muparfostat.

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