Genotypes |
Cases |
|
Controls |
|
P† |
Crude OR
(95% CI) |
Adjusted OR# (95% CI) |
P‡ |
(n=311) |
|
(n= 425) |
|
n |
% |
n |
% |
VEGFrs1547651(A/T) |
|
|
|
|
0.228 |
|
|
|
AA |
235 |
75.6 |
337 |
80.0 |
|
1.00 |
1.00 |
|
AT |
75 |
24.1 |
81 |
19.2 |
|
1.33(0.93-1.90) |
1.33(0.93-1.90) |
0.116 |
TT |
1 |
0.3 |
3 |
0.7 |
|
0.48(0.05-4.62) |
0.49(0.05-4.81) |
0.541 |
AT+TT |
76 |
24.4 |
84 |
19.9 |
|
1.30(0.91-1.85) |
1.30(0.92-1.85) |
0.142 |
T allele |
0.124 |
|
0.103 |
|
0.220 |
|
|
|
VEGFrs699947(C/A) |
|
|
|
|
0.162 |
|
|
|
CC |
166 |
53.9 |
212 |
50.0 |
|
1.00 |
1.00 |
|
AC |
119 |
38.6 |
190 |
44.8 |
|
0.80(0.59-1.09) |
0.80(0.59-1.09) |
0.152 |
AA |
23 |
7.5 |
22 |
5.2 |
|
1.34(0.72-2.48) |
1.36(0.73-2.53) |
0.332 |
AC+AA |
142 |
46.1 |
212 |
50.0 |
|
0.86(0.64-1.15) |
0.86(0.64-1.15) |
0.297 |
A allele |
0.268 |
|
0.276 |
|
0.732 |
|
|
|
VEGFrs2010963(G/C) |
|
|
|
|
0.972 |
|
|
|
GG |
96 |
31.4 |
135 |
32.1 |
|
1.00 |
1.00 |
|
CG |
154 |
50.3 |
210 |
50.0 |
|
1.03(0.74-1.44) |
1.03(0.74-1.44) |
0.874 |
CC |
56 |
18.3 |
75 |
17.9 |
|
1.05(0.68-1.62) |
1.04(0.67-1.61) |
0.858 |
CG+CC |
210 |
68.6 |
285 |
67.9 |
|
1.04(0.76-1.42) |
1.04(0.76-1.42) |
0.825 |
C allele |
0.435 |
|
0.429 |
|
0.818 |
|
|
|
VEGFrs1005230(C/T) |
|
|
|
|
0.111 |
|
|
|
CC |
168 |
54.7 |
212 |
50.0 |
|
1.00 |
1.00 |
|
CT |
116 |
37.8 |
190 |
44.8 |
|
0.77(0.57-1.05) |
0.77(0.57-1.05) |
0.095 |
TT |
23 |
7.5 |
22 |
5.2 |
|
1.320.71-2.45) |
1.34(0.72-2.50) |
0.352 |
CT+TT |
139 |
45.3 |
212 |
50.0 |
|
0.83(0.62-1.11) |
0.83(0.61-1.11) |
0.206 |
T allele |
0.264 |
|
0.276 |
|
0.607 |
|
|
|
VEGFrs735286(G/A) |
|
|
|
|
0.923 |
|
|
|
GG |
94 |
30.5 |
135 |
31.8 |
|
1.00 |
1.00 |
|
AG |
161 |
52.3 |
216 |
50.9 |
|
1.07(0.77-1.49) |
1.07(0.76-1.49) |
0.704 |
AA |
53 |
17.2 |
73 |
17.2 |
|
1.04(0.67-1.62 |
1.02(0.66-1.59) |
0.931 |
AG+AA |
214 |
69.5 |
289 |
68.1 |
|
1.06(0.77-1.46) |
1.06(0.77-1.46) |
0.708 |
A allele |
0.433 |
|
0.427 |
|
0.803 |
|
|
|
VEGFrs833052(C/A) |
|
|
|
|
0.736 |
|
|
|
CC |
135 |
43.5 |
192 |
45.9 |
|
1.00 |
1.00 |
|
AC |
147 |
47.4 |
186 |
44.5 |
|
1.12(0.83-1.53) |
1.13(0.83-1.53) |
0.454 |
AA |
28 |
9.0 |
40 |
9.6 |
|
1.00(0.59-1.69) |
1.00(0.59-1.70) |
0.997 |
CA+AA |
175 |
56.3 |
226 |
54.1 |
|
1.10(0.82-1.48) |
1.10(0.82-1.48) |
0.516 |
A allele |
0.327 |
|
0.318 |
|
0.709 |
|
|
|
VEGFrs833068(G/A) |
|
|
|
|
0.336 |
|
|
|
GG |
97 |
31.4 |
134 |
31.7 |
|
1.00 |
1.00 |
|
|
AG |
145 |
46.9 |
215 |
50.8 |
|
0.93(0.67-1.30) |
0.93(0.67-1.30) |
0.680 |
AA |
67 |
21.7 |
74 |
17.5 |
|
1.25(0.82-1.91) |
1.24(0.81-1.89) |
0.318 |
AG+AA |
212 |
68.6 |
289 |
68.3 |
|
1.01(0.74-1.39) |
1.01(0.74-1.39) |
0.932 |
A allele |
0.451 |
|
0.429 |
|
0.394 |
|
|
|
VEGFrs833070(G/A) |
|
|
|
|
0.057 |
|
|
|
GG |
184 |
59.5 |
232 |
52.7 |
|
1.00 |
1.00 |
|
AG |
106 |
34.3 |
181 |
42.8 |
|
0.71(0.52-0.97) |
0.71(0.52-0.96) |
0.028 |
AA |
19 |
6.1 |
19 |
4.5 |
|
1.21(0.62-2.36) |
1.22(0.63-2.37) |
0.564 |
AG+AA |
125 |
40.4 |
200 |
47.3 |
|
0.76(0.56-1.02) |
0.76(0.56-1.02) |
0.064 |
A allele |
0.233 |
|
0.259 |
|
0.258 |
|
|
|
VEGFrs3024994(C/T) |
|
|
|
|
0.697 |
|
|
|
CC |
277 |
90.2 |
379 |
89.6 |
|
1.00 |
1.00 |
|
CT |
30 |
9.8 |
42 |
9.9 |
|
1.02(0.63-1.68) |
1.02(0.62-1.67) |
0.949 |
TT |
0 |
0 |
2 |
0.5 |
|
|
|
|
CT+TT |
30 |
9.8 |
44 |
10.4 |
|
0.93(0.57-1.52) |
0.94(0.57-1.53 |
0.796 |
T allele |
0.049 |
|
0.054 |
|
0.640 |
|
|
|
VEGFrs3025007(C/T) |
|
|
|
|
0.077 |
|
|
|
CC |
164 |
53.8 |
198 |
47.0 |
|
1.00 |
1.00 |
|
CT |
110 |
36.1 |
187 |
44.4 |
|
0.71(0.52-0.97) |
0.71(0.52-0.97) |
0.034 |
TT |
31 |
10.2 |
36 |
8.6 |
|
1.04(0.62-1.75) |
1.04(0.62-1.76) |
0.882 |
CT+TT |
141 |
46.3 |
223 |
53.0 |
|
0.76(0.57-1.03) |
0.76(0.57-1.03) |
0.075 |
T allele |
0.282 |
|
0.308 |
|
0.291 |
|
|
|
VEGFrs3025021(C/T) |
|
|
|
|
0.102 |
|
|
|
CC |
231 |
75.2 |
302 |
71.4 |
|
1.00 |
1.00 |
|
CT |
65 |
21.2 |
113 |
26.7 |
|
0.75(0.53-1.07) |
0.75(0.53-1.07) |
0.111 |
TT |
11 |
3.6 |
8 |
1.9 |
|
1.80(0.71-4.54) |
1.84(0.73-4.67) |
0.197 |
CT+TT |
76 |
24.8 |
121 |
28.6 |
|
0.82(0.59-1.15) |
0.82(0.59-1.15) |
0.252 |
T allele |
0.142 |
|
0.152 |
|
0.567 |
|
|
|
VEGFrs3025030(G/C) |
|
|
|
|
0.143 |
|
|
|
GG |
200 |
65.6 |
259 |
62.9 |
|
1.00 |
1.00 |
|
CG |
92 |
30.2 |
144 |
35.0 |
|
0.83(0.60-1.14) |
0.83(0.60-1.14) |
0.254 |
CC |
13 |
4.3 |
9 |
2.2 |
|
1.87(0.78-4.46) |
1.92(0.80-4.59) |
0.144 |
CG+CC |
105 |
34.5 |
153 |
37.2 |
|
0.89(0.65-1.21) |
0.89(0.65-1.22) |
0.468 |
C allele |
0.193 |
|
0.197 |
|
0.881 |
|
|
|
VEGFrs3025035(C/T) |
|
|
|
|
0.555 |
|
|
|
CC |
203 |
65.9 |
290 |
68.4 |
|
1.00 |
1.00 |
|
CT |
94 |
30.5 |
124 |
29.2 |
|
1.08(0.78-1.50) |
1.08(0.79-1.50) |
0.623 |
TT |
11 |
3.6 |
10 |
2.4 |
|
1.57(0.66-3.77) |
1.56(0.65-3.76) |
0.320 |
CT+TT |
105 |
34.1 |
134 |
31.6 |
|
0.89(0.65-1.22) |
1.12(0.82-1.53) |
0.470 |
T allele |
0.188 |
|
0.170 |
|
0.360 |
|
|
|
VEGFrs3025039(C/T) |
|
|
|
|
0.064 |
|
|
|
CC |
206 |
68.4 |
276 |
66.8 |
|
1.00 |
1.00 |
|
CT |
83 |
27.6 |
131 |
31.7 |
|
0.85(0.61-1.18) |
0.86(0.62-1.19) |
0.364 |
|
TT |
12 |
4.0 |
6 |
1.5 |
|
2.68(0.99-7.26) |
2.61(0.96-7.10) |
0.060 |
CT+TT |
95 |
31.6 |
137 |
33.2 |
|
0.93(0.68-1.28) |
0.94(0.68-1.29) |
0.693 |
T allele |
0.178 |
|
0.173 |
|
0.821 |
|
|
|
# Adjusted for age and gender in a logistic regression model.
† Two-sided ?2 test for either genotype distribution or allele frequency.
‡ Two-sided ?2 test for difference in frequency distribution of genotype between cases and controls by adjusted for age and gender. |
| Table 1: Genotype frequencies of VEGF polymorphisms in the GC cases and the controls. |
