| |
Supplementation (n=7) |
Placebo (n=6) |
Comparisonaa) |
| Variables: mean (SD) |
4 week |
8 week |
12 week |
16 week |
4 week |
8 week |
12 week |
16 week |
F |
P |
| ADI-R repetitive behavior domains |
|
|
|
|
|
|
|
|
|
|
Encopassin b)
preoccupatuion |
3.1 (1.5) |
3.4 (0.8) |
3.0 (1.5) |
2.6 (1.5) |
2.8 (1.6) |
2.0 (1.8) |
2.3 (1.6) |
2.0 (1.8) |
1.46 |
0.25 |
Compulsive
adherencebc) |
1.4 (1.5) |
0.7 (0.8) |
2.9 (1.6) |
0.0 (0.0) |
0.5 (1.2) |
0.3 (0.8) |
1.8 (1.8) |
0.0 (0.0) |
0.59 |
0.62 |
Stereotyped and repetitive
motor mannerismsd) |
0.0 (0.0) |
0.0 (0.0) |
0.0 (0.0) |
0.0 (0.0) |
0.8 (1.6) |
0.3 (0.8) |
0.2 (0.4) |
0.0 (0.0) |
3.18 |
0.04* |
Preoccupation with
parts of objectse) |
2.3 (1.5) |
2.3 (1.1) |
2.1 (1.3) |
1.7 (1.4) |
2.0 (1.3) |
1.8 (1.2) |
2.1 (1.3) |
1.5 (1.2) |
1.15 |
0.35 |
| ABC |
|
|
|
|
|
|
|
|
|
|
| Irritability |
13.0 (11.6) |
10.6 (10.4) |
14.4 (14.3) |
8.9 (9.9) |
8.2 (7.7) |
8.3 (6.3) |
8.0 (7.1 |
9.2 (8.8) |
1.78 |
0.17 |
| Social withdrawal |
22.1 (4.6) |
13.3 (3.8) |
14.4 (8.8) |
10.9 (5.1) |
18.0 (2.8) |
18.2 (7.1) |
15.0 (5.1) |
17.7 (4.3) |
3.08 |
0.04* |
| Stereotypy |
5.1 (4.5) |
2.4 (2.9) |
4.4 (7.5) |
3.4 ( 4.9) |
3.8 (4.5) |
2.7 (3.8) |
4.0 (4.3) |
5.2 (5.7) |
0.66 |
0.58 |
| Hyperactivity |
15.0 (9.6) |
9.0 (8.4) |
14.6 (12.6) |
12.0 (10.7) |
14.2 (14.1) |
12.0 (9.4) |
15.7 (7.6) |
15.3 (8.1) |
0.65 |
0.59 |
| Inappropriate speech |
3.7 (3.6) |
3.0 (3.1) |
4.4 (4.9) |
3.7 (3.9) |
3.8 (2.1) |
3.8 (2.1) |
4.0 (2.8) |
5.3 (4.1) |
0.79 |
0.51 |
|
Treatment group received supplementation with arachidonic acid (ARA) and docosahexaenoic acid (DHA) for 16 weeks.
ADI-R, Autism Diagnostic Interview- Revised; ABC, Aberrant Behavior Checklist.
1) Repeated measures analysis of variance (ANOVA) was used when baseline scores as a covariate with treatment as the between-subject-factor and test session repeated
factor, * P<0.05.
2) ADI-R algorithm item C 1: Encompassing preoccupation or circumscribed pattern of interest.
3) ADI-R algorithm item C 2: Apparently compulsive adherence to nonfunctional routines or rituals.
4) ADI-R algorithm item C 3: Stereotyped and repetitive motor mannerisms.
5) ADI-R algorithm item C 4: Preoccupation with parts of objects or nonfunctional elements of materials. |
| Table 2: Mean scores on the Aberrant Behavior Checklist (ABC) and the Social Responsiveness Scale (SRS) for a 16-week randomized double-blind placebo-controlled trial. |
