| Variables |
Total (n=100) |
No cognitive impairment
(n=25) |
Cognitive impairment a (n=75) |
P value |
| Age>50 years |
18 |
6 |
12 |
0.36 |
| Male sex |
75 |
21 |
54 |
0.23 |
| African-American race |
71 |
16 |
55 |
0.44 |
| Education
≤ 12 years |
68 |
13 |
55 |
0.08 |
| Unemployed |
50 |
16 |
34 |
0.16 |
| CD4 nadir <200 b |
32 |
9 |
23 |
0.39 |
| HIV viral load
≥100,000 copies/ml |
31 |
8 |
23 |
0.54 |
| Homosexual risk factor |
45 |
7 |
38 |
0.06 |
| RPR Positive |
22 |
5 |
17 |
0.51 |
| Hepatitis B seropositive |
30 |
11 |
19 |
0.08 |
| Hepatitis C seropositive |
15 |
2 |
13 |
0.34 |
| Urine drug screen positive c |
38 |
9 |
29 |
0.81 |
| Moderate/severe depression d |
41 |
7 |
34 |
0.16 |
| MoCA score <26 e |
79 |
15 |
64 |
0.01 |
a defined as greater than 1.5 standard deviation below the mean on 2 or more
neuropsychological measures;
b CD4<200 at initial evaluation;
c cannabinoids (22), cocaine (11), opiates (11), amphetamines (3), PCP (2),
benzodiazepines (2), polysubstance abuse (13);
d Beck’s Depression Inventory score;
e diagnostic accuracy of the MoCA: sensitivity: 85%; specificity: 40%; negative predictive
value: 48%; positive predictive value: 81%. |
