|
|
Bivariate analysis |
Multivariate analysis, n = 793 |
|
Occurrence |
Cox |
|
Fine-Gray |
|
Cox |
Fine-Gray |
Characteristics |
n = 1136 |
% |
HR$crude[80% CI] |
P |
SHR¶crude[80% CI] |
P |
HRajusted[95% CI] |
P* |
SHRajusted[95% CI] |
P* |
Year of first HAART |
|
|
|
0.1448 |
|
0.0043 |
|
0.3461 |
|
0.0191 |
[2000–2001] |
43 |
13.74 |
1(Reference) |
|
1(Reference) |
|
1(Reference) |
|
1(Reference) |
|
[2002–2003] |
32 |
13.22 |
1.18 [0.87–1.59] |
|
1.02 [0.76–1.38] |
|
1.09 [0.59–1.98] |
|
0.97 [0.55–1.73] |
|
[2004– 2005] |
16 |
6.32 |
0.72 [0.49–1.06] |
|
0.50 [0.34–0.73] |
|
0.53 [0.23–1.21] |
|
0.36 [0.16–0.78] |
|
[2006– 2008] |
10 |
3.05 |
0.55 [0.34–0.87] |
|
0.38 [0.24–0.59] |
|
0.68 [0.27–1.72] |
|
0.43 [0.17–1.06] |
|
First HAART regimen |
|
|
|
0.0001 |
|
0.0001 |
|
0.0060 |
|
0.0444 |
2NRTI + 1PI/1PIb‡ |
19 |
4.68 |
1(Reference) |
|
1(Reference) |
|
1(Reference) |
|
1(Reference) |
|
2NRTI + 1NNRTI |
28 |
7.37 |
1.20 [0.82–1.77] |
|
1.53 [1.04–2.24] |
|
1.70 [0.79–3.67] |
|
1.82 [0.84–3.94] |
|
Other regimens |
54 |
15.43 |
2.66 [1.88–3.75] |
|
2.86 [2.03–4.02] |
|
2.94 [1.47–5.88] |
|
2.38 [1.20–4.71] |
|
HIV seropositivity duration (years) |
|
|
|
0.0032 |
|
0.0011 |
|
0.0094 |
|
0.0039 |
<0.169 |
28 |
9.89 |
1(Reference) |
|
1(Reference) |
|
1(Reference) |
|
1(Reference) |
|
[0.16– 1.83] |
13 |
4.56 |
0.45 [0.29–0.69] |
|
0.49 [0.32–0.76] |
|
0.64 [0.29–1.39] |
|
0.68 [0.30–1.52] |
|
[1.83– 8.27] |
18 |
6.34 |
0.56 [0.38–0.82] |
|
0.65 [0.44–0.95] |
|
0.80 [0.35–1.83] |
|
0.68 [0.30–1.53] |
|
[8.27– 24.02] |
42 |
14.79 |
1.19 [0.87–1.63] |
|
1.45 [1.06–1.99] |
|
1.92 [1.04–3.54] |
|
1.94 [1.05–3.58] |
|
AIDS-defining illness |
n=1092 |
100% |
|
0.0059 |
|
0.1239 |
|
0.0311 |
|
0.1201 |
No |
76 |
8.08 |
1(Ref) |
|
1(Ref) |
|
1(Ref) |
|
1(Ref) |
|
Yes |
18 |
11.92 |
2.06 [1.47–2.88] |
|
1.50 [1.07–2.11] |
|
2.05 [1.06–3.95] |
|
1.74 [0.86–3.50] |
|
* P-value obtained by backward stepwise regression
** Ti =Time of HAART initiation
‡ PIb = boosted protease inhibitor
$ Hazard Ratio obtained by Cox model
¶ Subdistribution Hazards Ratio obtained by Fine-Gray model |