Effects ofthe Functional

Variable	Sub-Cohort Mean ± SD (n = 58)	Parameter Estimate	Standard Error	T-value	P-value
HIV viral load (copies/mL)^A	29,058±137,990	-0.918	0.385	-2.39	0.022*
CD4 cell count (cells/uL)^A	557 ± 355	1.236	2.467	0.50	0.619
Oxidized glutathione(%)	26.49 ± 10.43	10.021	4.156	2.41	0.028*
MDA (uM)	0.54 ± 0.25	0.030	0.087	0.34	0.736
Mitochondrial 8-oxo-dG (ΔCt)	0.44 ± 0.53	-0.478	0.201	-2.38	0.028*
Complex I enzyme activity (%)	46.85 ± 16.36	-0.216	7.593	-0.03	0.978
Complex IV enzyme activity (%)	21.96 ± 14.65	-4.946	4.093	-1.21	0.246
Apoptosis (CK18 Average value (pM)^B	130.49 ± 80.47	-67.489	22.453	-3.01	0.009*

*Indicates statistically significant results. P-value associated with linear regression analysis. Participants with BMI>28 kg/m² excluded from regression analysis.
^A No exclusion of participants with BMI>28 in this analysis.
^B Participants who consume alcohol excluded.

Table 4: Effects ofthe Functional (Non-Null) GSTM1 Genotype on HIV Disease Progression and Oxidative Stress in HIV/HCV Co-Infected Sub-Cohort.

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