Patient Age Sex Primary diagnostic Concomitant diseases Chronic medication HS reaction Final dose (mg) Complications
1 73 M Gouty joint pathology HBP Losartan
Colchicine
Fixed erythema 300 2nd day: Fixed erythema (oral antihistamine and topical corticosteroid)
2 76 M Hyperuricemia with chronic renal failure HBP Colchicine
Trimetazidine
Candesartan/HCTZ
Carvedilol Lercanidipine
Fibrate
Alprazolam
Clopidogrel
Fixed erythema 100 3th and 6th days: Fixed erythema
3 57 M Gouty joint pathology HBP
Coronary disease
FA Dyslipidemia
Colchicine
Valsartan
Bisoprolol
Clopidogrel
Statin
AAS
Late onset anaphylaxis 300 0
4 78 M Gouty joint pathology HBP
NIDDM Valvulopathy
Fursosemide
Perindopril
Metformin
Sitagliptine
Colchicine
Carvedilol
Oxazepam
Urticaria 300 0
5 62 M Gouty joint pathology HBP
DVT
Eterocoxib
Trimetazidine
Diclofenac Glucosamine
Urticaria 300 4th and 6th days: Urticaria
7th and 9th days: Fixed erythema (IM antihistamine, daily  antihistamine after)
6 80 F Gouty joint pathology HBP
Dyslipidemia
Alprazolam Trimetaxidine
Statin
AAS
Candesartan Glucosamine
MPE 150 7th day: MPE (IM  antihistamine and IV corticoid)
7 37 M Gouty joint pathology and uric nephropaty   Losartan
Fenofibrate
Fixed erythema 200 0
Table 3: Clinical characteristics, hypersensitivity reaction to allopurinol and adverse reactions during desensitization procedure.
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