| Publication |
Target |
Probiotic Intake (from/until) |
Study |
Findings and Summary |
| Kim et al. [79] |
pregnant women
with family history of allergic disease |
Mixture of 2 strains
32 w.gestation/ 3m postnatally |
RDBPC |
No difference in food sensitization or probable food allergy in treatment
versus placebo groups after 1 year |
| Niers et al. [78] |
pregnant women
with family history of allergic disease |
Mixure of 3 strains
34 w.gestation/ 12m postnatally |
RDBPC |
No difference in food sensitization in treatment versus placebo after 1 & 2y. |
| Boyle et al. [81] |
pregnant women
with family history of allergic disease |
Lactobacillus GG
36 w.gestation/ until delivery |
RDBPC |
No difference in food sensitization in treatment versus placebo after 1 year |
| Dotterud et al. [80] |
Nonselected maternal population |
Mixure of 3 strains
36th w.gestation/ 3m postnatally |
RDPPC |
Reduced cumulative incidence of atopic dermatitis, but no effect on atopic sensitization |
Kuitunen et al.
(2009) [83]
Kukkonen et al. (2011) [84]
Kuitunen et al. (2012) [85] |
pregnant women
with family history of allergic disease
same cohort
same cohort |
Mixure of 4 strains
36 w.gestation/ 6m postnatally
|
RDPPC |
No difference in cumulative incidence of allergic diseases and IgE sensitization versus placebo at 5 y.
No difference on serum food-specific IgA, IgG1 or IgG4 concentrations versus placebo at age 2y
Increased IL-10 and decreased casein IgA Abs in breast milk from mothers treated with probiotic vs placebo. |
| Ou et al. [82] |
pregnant women
with personal history of allergic disease |
Lactobacillus GG
24 w.gestation/ until delivery |
RDPPC |
Reduced severity of maternal allergic disease but not the incidence of childhood allergic disease. |
